What is UT-Aflatrol?
Aflatrol is presently
showing a high
potential for aflatoxin
mycotoxin binding in animal feeds and field studies indicate other
benefits from the effects of this product.
Aflatrol contains natural highly
adsorbent montmorillonite layered silicate mineral clays and humified vegetable
carbons with a honey comb pores structure, containing a myriad of
substances found in several naturally occurring deposits of minerals
produced by metamorphic and sedimentary activities of the earth's geology
millions of years ago.
Aflatrol also contains MOS mannan
glucomannans and fructose oligosaccharides,
dried lactobacillus acidophilus whey fermentation solubles combined with
specific botanical herbal extracts known for their nutraceutical effects
in animal feeds.
The ingredients contained in Aflatrol
are not affected by high extrusion
temperatures or pelleting
The ingredients contain aggregate
that act as chelating agents which can mobilize
nutrients across various tissue membranes, thereby increasing the
bio-availability of nutrients, especially minerals within the animals
feed. These nutrients are often complexed (tied-tip) by such agents
phytates and phosphates etc.
In addition to the benefits associated with
the physical dynamics of UT-Alphatrol Premix, it also provides a
nutrient-dense source of rare, naturally chelated macro and micro
nutrients which are no longer readily supplied by various feed-stuffs due
to soil depletion and processing methods.
Alphatol is a source of biosis factors,
pathogen inhibition resulting
from the addition lactobacillus acidophilus whey fermentation solubles rich
in lactic acid, lactose, amino acids and other undefined nutrient factors
(U.N.F's.) created during the fermentation process.
Effects of Mycotoxins
in Animal Feeds (NC State University)
are sensitive to mycotoxins, especially nursing or nursery-age swine. In general, mycotoxins cause
reductions in feed intake, growth performance, and immune function when
levels are relatively low. Producers must be aware that if one toxin is
identified in a sample, the chances are high that other toxins are
present. Some toxins may not have been identified as of yet, but research
on known mycotoxins provides insight into the expected effects in swine
and potential methods to reduce those effects. Table 3 contains a summary
of the maximum permissible concentrations of mycotoxins in swine feeds.
Aflatoxin B1 has been the most
extensively studied. Twenty to
200 ppb will cause a decrease in feed intake and growth performance, which
can be partially offset by increasing specific dietary nutrients such as
lysine or methionine. In severe cases (1,000 to 5,000 ppb) of
aflatoxicosis, one can expect acute effects including death. Aflatoxin M1
appears in milk of sows consuming aflatoxin-contaminated diets and may
affect piglets nursing those sows.
Feed concentrations of deoxynivalenol
(DON) of 300 to 500 ppb are often
associated with feed refusal, decreased weight gain, and increased
incidence of infectious diseases. DON levels greater than 1000 ppb, will
cause feed refusal or decrease in feed intake resulting in severe weight
loss. It appears that pigs will often consume a sufficient amount of
contaminated feed to induce vomiting. In fact, DON is also called
vomitoxin because of its association with swine vomiting.
T-2 toxin has detrimental effects on
swine performance, but no effect
levels have not been determined for commercial production environments.
However, field observations indicated that T-2 and related compounds are
associated with decreased productivity at feed concentrations of 200 ppb
Zearalenone will significantly affect the
reproductive performance of
swine. Prepuberal gilts are the most sensitive to zearalenone. The
symptoms commonly observed when feeding diets contaminated with
zearalenone include a reddening and increased size of the vulva, and
increased size of mammary tissue. Zearalenone will cause embryonic
mortality at certain stages of gestation. Fertility problems are often
associated with zearalenone concentrations of 100 to 200 ppb in sow feeds.
affects all poultry species. Although it generally takes relatively high levels to cause mortality, low
levels can be detrimental if continually fed. Young poultry, especially
ducks and turkeys, are very susceptible. As a general rule, growing
poultry should not receive more than 20 ppb aflatoxin in the diet.
However, feeding levels lower than 20 ppb may still reduce their
resistance to disease, decrease their ability to withstand stress and
bruising, and generally make them unthrifty.
Laying hens generally can tolerate higher
levels than young birds, but
levels should still be less than 50 ppb. Aflatoxin contamination can
reduce the birds' ability to withstand stress by inhibiting the immune
system. This malfunction can reduce egg size and possibly lower egg
production. In addition, one must pay special attention to the use of
contaminated corn in layer rations because eggs are promptly used as human
food and aflatoxin metabolites have been found in egg yolks.
levels found in most field situations tend to be low.
Yet the combination of low levels of
mycotoxins with the stresses associated with commercial production
situations and/or exposure to disease organisms can produce effects in
poultry which are subtle, indirect, and sometimes ill-defined. Since the
effects of mycotoxins on poultry are dependant upon the age, physiological
state, and nutritional status of the animals at the time of exposure, and
since mold growth at various points within the feed production and
distribution system can magnify mycotoxin problems, mycotoxicoses can be
difficult to diagnose in field situations.
Mycotoxins produced by the mold genus
Fusarium include: T-2 toxin and
it's chemical relatives (trichothecenes), deoxynivalenol (DON), fumonisin,
and zearalenone. Other animals tend to be more sensitive to the effects of
fumonisin, deoxynivalenol, and zearalenone when compared to poultry.
Nevertheless, detection of these mycotoxins within poultry rations
indicates that the ration or the ingredients within the ration have been
subjected to mold activity. Since numerous other mycotoxins, as well as
reduced nutritive value and palatability of feeds, are generated by mold
activity, the presence of fumonisin, deoxynivalenol, or zearalenone in
poultry feeds is cause for concern.
T-2 toxin and trichothecenes can cause
mouth and intestinal lesions as
well as impair the birds' immune response, causing egg production
declines, decreased feed consumption, weight loss, and altered feather
patterns. While much is yet to be learned, T-2 toxin and related compounds
are currently thought to be the most potent Fusarium mycotoxin for
DON alone has few effects in poultry.
However, in field situations the
DON level is sometimes associated with reduced feed consumption in layers
and broiler breeders. This means that DON may be an indicator that T-2 or
other unknown Fusarium mycotoxins are present.
overall health, but it also creates risks of residues in milk. Aflatoxin
is secreted into milk in the form of aflatoxin M1 with residues
approximately equal to 1 to 2 percent (1.7 percent average) of the dietary
level. This ratio is not influenced greatly by milk production level since
higher producing cows consume more feed and have a slightly higher
transmission rate. Due to risks of milk residues, dietary aflatoxin should
be kept below 25 ppb. This level is conservative due to: (1) nonuniform
distribution of aflatoxin in grain and feed, (2) uncertainties in sampling
and analysis, and (3) the potential for having more than one source of
aflatoxin in the diet. Replacement animals may tolerate 50 to 100 ppb
Aflatoxin-contaminated feed not only
In dairy cattle DON is associated with
reduced feed intake, lower milk
production, elevated milk somatic cell counts, and reduced reproductive
efficiency. Milk production loss appears to occur when diets contain more
than 300 ppb DON. Although controlled research has shown no cause and
effect relationship between DON levels and reduced milk production, field
observations have shown that reductions in milk output of 25 pounds per
cow were seen when DON was 500 ppb or more. This suggests that DON may
serve as a marker for feed that was exposed to a situation conducive to
mold growth and mycotoxin formation. The possible presence of other
mycotoxins, or factors more toxic than DON, seems likely. Dietary levels
of 300 to 500 ppb DON in dairy feeds indicate mycotoxin problems and
Zearalenone causes estrogenic responses
in dairy cattle, and large doses
of this toxin are associated with abortions. Other responses of dairy
animals to zearalenone may include reduced feed intake, decreased milk
production, vaginitis, vaginal secretions, poor reproductive performance,
and mammary gland enlargement in virgin heifers. Establishment of a
tolerable level of zearalenone for dairy cattle is difficult, and is at
best only a guess based on a meager amount of data and field observations.
As with DON, zearalenone may serve as a marker for toxic feed. It is
suggested that zearalenone not exceed 250 ppb in the total diet.
In dairy cattle T-2 toxin has been
associated with feed refusal, production losses, gastroenteritis, intestinal hemorrhages, and death. T-2
has also been associated with reduced immune response in calves. Data with
dairy cattle are not sufficient to establish a tolerable level of T-2 in
the diet. Therefore, a practical recommendation may be to avoid T-2 in
excess of 100 ppb in the total diet for growing or lactating dairy
Fumonisin is another commonly isolated
mycotoxin. However, fumonisin has
only recently been isolated and only enough data exist to know that levels
in excess of 20,000 ppb are potentially toxic to ruminants.
and other mycotoxins can have considerable effects on beef cattle
although the problems are usually less
critical than for swine and poultry. Consumption of feeds highly
contaminated with aflatoxin may reduce growth rate and increase the amount
of feed required per pound of gain. Calves are generally more sensitive to
feed contamination than adult cattle. In affected calves, some cases have
revealed severe rectal straining and a prolapsed rectum. Lactating cows
show a significant reduction in milk yield. Research has shown that high
levels of aflatoxin can also cause liver damage in adult cattle. Feeding a
high level of aflatoxin may also depress immune function, resulting in
Based on the feeds available, those
contaminated with aflatoxin should be fed at the lowest level possible and for the shortest period of
time practical. The effects of aflatoxin fed to cattle depend on the level
of aflatoxin in the ration, the length of the feeding period, and the age
of the animal. If aflatoxin-contaminated feeds must be fed to beef cattle,
follow these guidelines (on a dry matter basis):
- Creep feeds and diets for gestating
and lactating beef cows should contain less than 20 ppb of aflatoxin.
- Unstressed, growing-finishing cattle
in excess of 400 pounds may be fed diets containing up to 100 ppb of
- Diets for stressed feeder cattle
should contain no more than 20 ppb of aflatoxin. Stressful conditions
include weaning, shipping, extreme heat or cold, diseases, and
- Animals destined for slaughter should
receive aflatoxin-free diets for at least 3 weeks before slaughter.
Since cattle in the southeast are
typically fed high forage diets,
they are usually fed grain only as a supplement. Thus a relatively high
level of aflatoxin can occur in the grain before it exceeds the tolerable
dietary level. In general, cattle will eat about 2.5 percent of their body
weight as dry matter. This can be used to calculate the contribution of
grain to their total ration, and the tolerable level of aflatoxin in the
grain. For example, growing calves weighing 600 pounds will consume about
15 pounds of total feed (600 lb multiplied by 2.5% equals 15 lb). If they
are fed 3 pounds of grain plus forage-to-appetite, the grain will make up
about 20 percent of their total diet (3 lb divided by 15 lb equals 20%).
In this case the grain may contain up to 500 ppb of aflatoxin (100 ppb
divided by 20% equals 500 ppb). Aflatoxin levels allowable in the grain,
given different rates of inclusion in the beef ration. (NC State
Test Results & Registrations
Results - Taiwan Registration No. 901032309 (Mycotoxin Binder)
Properties at 300g/ton/inclusion rate/% of reduction)
The above government test
was conducted on corn and soya feed grains.
UT-Aflatrol is registered
in Taiwan and many parts
of Asia, Latin America, North America under private label and or / license
agreements. Most of the compiled research on this product which we
manufacture was compiled by our distributors.
Indications: UT-Aflatrol potential benefits when added to animal feeds:
Binding of numerous mycotoxins
(2) Helps reduce blood urea
(3) Provides naturally chelated minerals
(4) Normalize acid alkaline balance in gut
(5) Stimulates production of digestive enzymes
(6) Stimulates the growth and proliferation of
beneficial intestinal flora
(7) Improves feed conversion less fecal output with lower manure odors
economical inclusion rates
(300g to 2 Kg/metric/ton
or - 8 oz to 4 pounds)
Choice Cattle Cows Horses daily ration use 1/2 to 1 oz per/head/day
high temperature processing via extrusion/pelleting
- 25 Kg Fiber Kegs or feed mill bulk 1